Variation Browser

Download
Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ednrb_human 404 C-term W => Ter stop gained 0.0001626 5 30744 0 None None
ednrb_human 401 8.58x58 H8 L => Ter frameshift 8.291e-06 1 120612 0 None None
ednrb_human 391 8.48x48 H8 K => Ter frameshift 8.282e-06 1 120748 0 None None GP (contact)
ednrb_human 383 7.50x50 TM7 P => IlefsTer3 frameshift 8.28e-06 1 120766 0 None None SodiumPocket MicroSwitch
ednrb_human 291 5.56x56 TM5 F => Ter stop gained 8.279e-06 1 120786 0 None None
ednrb_human 57 N-term G => Ter stop gained 0.000209 24 114810 0 None None
ednrb_human 50 N-term T => TrpfsTer38 frameshift 3.485e-05 4 114770 0 None None
ednrb_human 50 N-term T => LeufsTer25 frameshift 8.713e-06 1 114770 0 None None
ednrb_human 32 N-term P => Ter stop gained 3.524e-05 4 113506 0 None None
ednrb_human 16 N-term V => GlyfsTer60 frameshift 9.049e-06 1 110504 0 None None
ednrb_human 13 N-term V => ArgfsTer63 frameshift 9.162e-06 1 109146 0 None None
ednrb_human 6 N-term S => Ter stop gained 5.063e-05 5 98764 0 None None
ednrb_human 441 C-term S => L missense 8.638e-06 1 115768 0 nan 0.878 PTM (Phosphorylation)
ednrb_human 436 C-term S => T missense 8.485e-06 1 117854 0 0.15 0.249 PTM (Phosphorylation)
ednrb_human 436 C-term S => G missense 8.474e-06 1 118006 0 0.05 0.747 PTM (Phosphorylation)
ednrb_human 435 C-term S => Y missense 8.46e-06 1 118208 0 0.02 0.993 PTM (Phosphorylation)
ednrb_human 434 C-term R => H missense 1.689e-05 2 118392 0 0.04 0.052
ednrb_human 434 C-term R => C missense 8.437e-06 1 118530 0 0.0 0.119
ednrb_human 434 C-term R => S missense 1.687e-05 2 118530 0 0.1 0.236
ednrb_human 430 C-term Y => H missense 8.388e-06 1 119222 0 0.22 0.702 PTM (Phosphorylation)
ednrb_human 429 C-term G => R missense 0.0001257 15 119360 0 0.01 0.956
ednrb_human 427 C-term D => G missense 8.361e-06 1 119608 0 0.26 0.713
ednrb_human 425 C-term A => P missense 8.347e-06 1 119804 0 0.09 0.905
ednrb_human 422 C-term K => E missense 0.0002583 31 120008 0 0.02 0.776
ednrb_human 419 C-term S => L missense 5.828e-05 7 120114 0 0.0 0.951 PTM (Phosphorylation)
ednrb_human 399 8.56x56 H8 S => T missense 2.502e-05 3 119884 1 0.03 0.033
ednrb_human 393 8.50x50 H8 F => L missense 8.321e-06 1 120178 0 0.01 0.987
ednrb_human 391 8.48x48 H8 K => R missense 6.649e-05 8 120324 0 0.17 0.274 GP (contact)
ednrb_human 384 7.51x51 TM7 I => V missense 8.3e-05 10 120476 0 0.17 0.893
ednrb_human 380 7.47x47 TM7 C => S missense 8.304e-06 1 120420 0 0.0 0.888
ednrb_human 371 7.38x37 TM7 G => S missense 8.335e-06 1 119976 0 0.2 0.148
ednrb_human 364 7.31x30 TM7 L => V missense 8.392e-05 10 119168 0 0.0 0.193 LB (hydrophobic, Van der Waals)
ednrb_human 348 6.60x60 TM6 T => S missense 8.276e-06 1 120828 0 0.04 0.511
ednrb_human 325 6.37x37 TM6 V => I missense 8.301e-06 1 120466 0 0.0 0.957 GP (contact)
ednrb_human 319 6.31x31 TM6 R => L missense 8.329e-06 1 120060 0 0.01 0.878
ednrb_human 319 6.31x31 TM6 R => W missense 2.499e-05 3 120062 0 0.02 0.431
ednrb_human 308 ICL3 Q => K missense 1.657e-05 2 120704 0 0.32 0.377
ednrb_human 305 5.70x70 TM5 S => N missense 0.008911 1076 120756 5 0.76 0.021 PTM (Phosphorylation)
ednrb_human 304 5.69x69 TM5 K => I missense 8.281e-06 1 120758 0 0.01 0.929 GP (contact)
ednrb_human 296 5.61x61 TM5 M => L missense 8.281e-06 1 120754 0 0.01 0.253 GP (contact)
ednrb_human 294 5.59x59 TM5 T => I missense 8.282e-06 1 120746 0 0.0 0.673
ednrb_human 275 5.40x41 TM5 W => S missense 8.328e-06 1 120084 0 0.0 0.985
ednrb_human 274 5.39x40 TM5 D => V missense 8.342e-06 1 119882 0 0.07 0.934 LB (polar (charge-assisted hydrogen bond))
ednrb_human 274 5.39x40 TM5 D => Y missense 8.342e-06 1 119882 0 0.01 0.997 LB (polar (charge-assisted hydrogen bond))
ednrb_human 274 5.39x40 TM5 D => N missense 5.839e-05 7 119882 0 0.01 0.992 LB (polar (charge-assisted hydrogen bond))
ednrb_human 270 5.35x36 TM5 K => Q missense 8.376e-06 1 119390 0 0.3 0.111 LB (Van der Waals, polar (charge-assisted hydrogen bond))
ednrb_human 260 ECL2 V => F missense 0.0007518 91 121042 0 0.69 0.022
ednrb_human 260 ECL2 V => I missense 0.0001652 20 121042 1 0.43 0.008
ednrb_human 259 ECL2 P => S missense 8.26e-06 1 121066 0 0.07 0.969
ednrb_human 258 ECL2 H => Q missense 1.652e-05 2 121078 0 0.31 0.022
ednrb_human 258 ECL2 H => D missense 3.303e-05 4 121086 0 0.06 0.027
ednrb_human 254 ECL2 I => T missense 8.256e-06 1 121128 0 0.68 0.02
ednrb_human 254 ECL2 I => L missense 8.256e-06 1 121126 0 0.13 0.063
ednrb_human 253 ECL2 R => Q missense 4.954e-05 6 121118 0 0.14 0.041
ednrb_human 252 ECL2 L => P missense 8.254e-06 1 121150 0 0.01 0.979
ednrb_human 250 ECL2 S => I missense 8.255e-06 1 121140 0 0.16 0.275
ednrb_human 250 ECL2 S => G missense 8.253e-06 1 121168 0 0.28 0.022
ednrb_human 249 ECL2 G => R missense 8.255e-06 1 121138 0 0.01 0.962
ednrb_human 248 ECL2 K => T missense 1.65e-05 2 121178 0 0.2 0.358
ednrb_human 247 ECL2 Y => C missense 1.65e-05 2 121190 0 0.0 0.917
ednrb_human 246 ECL2 D => G missense 8.252e-06 1 121190 0 0.03 0.287
ednrb_human 245 ECL2 M => I missense 8.252e-06 1 121176 0 0.32 0.003
ednrb_human 244 ECL2 T => M missense 0.001048 127 121172 0 0.04 0.84
ednrb_human 241 ECL2 D => A missense 1.65e-05 2 121182 0 0.01 0.356
ednrb_human 241 ECL2 D => N missense 8.251e-06 1 121198 0 0.26 0.029
ednrb_human 238 4.62x63 TM4 I => V missense 8.25e-06 1 121208 0 0.47 0.008
ednrb_human 225 4.49x49 TM4 I => T missense 8.248e-06 1 121236 0 0.0 0.997
ednrb_human 224 4.48x48 TM4 L => S missense 8.248e-06 1 121236 0 0.25 0.959
ednrb_human 211 34.55x55 ICL2 G => V missense 8.252e-06 1 121186 0 0.01 0.373 GP (contact)
ednrb_human 207 34.51x51 ICL2 S => N missense 8.256e-06 1 121126 0 0.17 0.062 GP (contact)
ednrb_human 203 3.54x54 TM3 V => L missense 8.264e-06 1 121014 0 0.0 0.756 GP (contact)
ednrb_human 201 3.52x52 TM3 R => P missense 8.272e-06 1 120894 0 0.0 0.992
ednrb_human 201 3.52x52 TM3 R => Q missense 8.272e-06 1 120894 0 0.02 0.755
ednrb_human 194 3.45x45 TM3 A => V missense 3.31e-05 4 120864 0 0.02 0.986
ednrb_human 185 3.36x36 TM3 V => M missense 0.0001157 14 120976 0 0.0 0.989 LB (hydrophobic, Van der Waals)
ednrb_human 180 3.31x31 TM3 I => M missense 2.484e-05 3 120758 0 0.0 0.81
ednrb_human 178 3.29x29 TM3 P => T missense 1.657e-05 2 120706 0 0.0 0.994 LB (hydrophobic, Van der Waals)
ednrb_human 176 3.27x27 TM3 L => V missense 9.116e-05 11 120666 0 0.02 0.344
ednrb_human 172 3.23x23 TM3 E => D missense 8.292e-06 1 120594 0 0.2 0.065
ednrb_human 172 3.23x23 TM3 E => A missense 8.293e-06 1 120582 0 0.51 0.012
ednrb_human 157 2.60x59 TM2 I => V missense 1.648e-05 2 121388 0 0.13 0.051 LB (hydrophobic, Van der Waals)
ednrb_human 154 2.57x56 TM2 D => G missense 8.237e-06 1 121402 0 0.44 0.014 LB (Van der Waals, polar (charge-assisted hydrogen bond))
ednrb_human 151 2.54x54 TM2 I => V missense 8.237e-06 1 121404 0 0.03 0.906
ednrb_human 141 2.44x44 TM2 A => S missense 8.237e-06 1 121402 0 0.1 0.733
ednrb_human 141 2.44x44 TM2 A => T missense 8.237e-06 1 121402 0 0.0 0.405
ednrb_human 139 2.42x42 TM2 L => F missense 8.237e-06 1 121406 0 0.09 0.456
ednrb_human 139 2.42x42 TM2 L => F missense 1.647e-05 2 121406 0 0.09 0.456
ednrb_human 139 2.42x42 TM2 L => V missense 8.237e-06 1 121406 0 0.01 0.775
ednrb_human 135 2.38x38 TM2 G => S missense 8.238e-06 1 121392 0 0.02 0.765
ednrb_human 130 12.48x48 ICL1 K => T missense 8.239e-06 1 121380 0 0.01 0.749
ednrb_human 124 1.55x55 TM1 R => K missense 8.24e-06 1 121362 0 0.1 0.083
ednrb_human 114 1.45x45 TM1 L => P missense 8.239e-06 1 121370 0 0.0 0.935
ednrb_human 113 1.44x44 TM1 V => M missense 8.239e-06 1 121368 0 0.04 0.921
ednrb_human 105 1.36x36 TM1 T => M missense 9.063e-05 11 121378 0 0.0 0.941
ednrb_human 104 1.35x35 TM1 N => I missense 3.295e-05 4 121384 0 0.0 0.343
ednrb_human 99 1.30x30 TM1 T => P missense 8.238e-06 1 121396 0 0.02 0.343
ednrb_human 95 1.26x26 TM1 E => V missense 8.238e-06 1 121394 0 0.02 0.36
ednrb_human 92 1.23x23 TM1 G => E missense 8.238e-06 1 121388 0 0.69 0.036
ednrb_human 88 N-term P => L missense 1.648e-05 2 121378 0 0.0 0.743
ednrb_human 87 N-term P => S missense 8.24e-06 1 121362 0 0.01 0.26
ednrb_human 84 N-term T => I missense 8.241e-06 1 121340 0 0.07 0.012
ednrb_human 84 N-term T => N missense 8.241e-06 1 121340 0 0.24 0.007
ednrb_human 83 N-term R => C missense 8.243e-06 1 121310 0 0.0 0.947
ednrb_human 81 N-term P => L missense 8.247e-06 1 121256 0 0.16 0.012
ednrb_human 76 N-term R => M missense 0.0001903 23 120862 0 0.01 0.712
ednrb_human 72 N-term P => S missense 1.667e-05 2 119984 0 0.06 0.164
ednrb_human 70 N-term E => K missense 5.018e-05 6 119566 0 0.33 0.005
ednrb_human 64 N-term R => L missense 8.48e-06 1 117928 0 0.3 0.001 PTM (Proteolytic Cleavage)
ednrb_human 64 N-term R => P missense 3.392e-05 4 117928 0 0.29 0.001 PTM (Proteolytic Cleavage)
ednrb_human 64 N-term R => W missense 8.495e-06 1 117714 0 0.07 0.001 PTM (Proteolytic Cleavage)
ednrb_human 64 N-term R => G missense 8.495e-06 1 117714 0 0.36 0.001 PTM (Proteolytic Cleavage)
ednrb_human 60 N-term A => P missense 8.599e-06 1 116286 0 0.15 0.559
ednrb_human 60 N-term A => T missense 1.72e-05 2 116286 0 0.15 0.006
ednrb_human 57 N-term G => S missense 0.00652 753 115482 7 0.19 0.015
ednrb_human 56 N-term K => T missense 3.467e-05 4 115360 0 0.15 0.002
ednrb_human 55 N-term P => R missense 1.738e-05 2 115066 0 0.03 0.23
ednrb_human 53 N-term L => S missense 8.739e-06 1 114432 0 0.69 0.002
ednrb_human 44 N-term E => V missense 8.895e-06 1 112424 0 0.03 0.376
ednrb_human 38 N-term P => L missense 8.943e-06 1 111822 0 nan 0.002
ednrb_human 36 N-term A => D missense 8.962e-06 1 111586 0 nan 0.009
ednrb_human 34 N-term D => E missense 6.273e-05 7 111586 0 nan 0.04
ednrb_human 32 N-term P => S missense 1.794e-05 2 111508 0 nan 0.023
ednrb_human 30 N-term G => D missense 8.973e-06 1 111450 0 nan 0.49
ednrb_human 23 N-term R => W missense 1.794e-05 2 111486 0 nan 0.784
ednrb_human 20 N-term G => S missense 1.792e-05 2 111632 0 nan 0.04
ednrb_human 17 N-term L => F missense 0.001564 175 111860 0 nan 0.019
ednrb_human 16 N-term V => F missense 1.791e-05 2 111664 0 nan 0.407
ednrb_human 11 N-term A => V missense 8.971e-06 1 111466 0 nan 0.056
ednrb_human 8 N-term C => G missense 9.042e-06 1 110598 0 nan 0.002
ednrb_human 5 N-term P => T missense 4.573e-05 5 109330 0 nan 0.015
ednrb_human 4 N-term P => A missense 9.229e-06 1 108356 0 nan 0.117
ednrb_human 3 N-term P => L missense 2.771e-05 3 108246 0 nan 0.009


Residue

Diagrams

ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
SnakePlot Download: PNG | SVG S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
HelixBox Download: PNG | SVG